Pixantrone dimaleate
Pixuvri (pixantrone dimaleate) is a small molecule pharmaceutical. Pixantrone dimaleate was first approved as Pixuvri on 2012-05-10. It has been approved in Europe to treat non-hodgkin lymphoma.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
FDA
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HCPCS
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Clinical
Clinical Trials
18 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | 4 | 4 | — | — | 11 |
| Lymphoma | D008223 | — | C85.9 | 4 | 5 | 2 | — | — | 10 |
| Follicular lymphoma | D008224 | — | C82 | 1 | 1 | 3 | — | — | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | 2 | 1 | — | 1 | 4 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | 1 | — | — | 2 |
| Leukemia | D007938 | — | C95 | 1 | 1 | 1 | — | — | 2 |
| Recurrence | D012008 | — | — | — | — | 1 | — | — | 1 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aggression | D000374 | EFO_0003015 | — | — | 1 | — | — | — | 1 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | — | 1 | — | — | — | 1 |
| Burkitt lymphoma | D002051 | — | C83.7 | — | 1 | — | — | — | 1 |
| Large-cell lymphoma immunoblastic | D016400 | — | — | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 1 | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| B-cell lymphoma | D016393 | — | — | 1 | — | — | — | — | 1 |
| Second primary neoplasms | D016609 | — | — | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Pixantrone dimaleate |
| INN | — |
| Description | Pixantrone is a member of isoquinolines. |
| Classification | Small molecule |
| Drug class | antineoplastics, anthraquinone derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCNc1ccc(NCCN)c2c1C(=O)c1ccncc1C2=O.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 144510-96-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103844 |
| ChEBI ID | — |
| PubChem CID | 134019 |
| DrugBank | DB06193 |
| UNII ID | — |
Target
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Additional graphs summarizing 54 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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10 adverse events reported
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